Translational buffering by ribosome stalling in upstream open reading frames
Ty Bottorff, Heungwon Park, Adam P. Geballe, Arvind Rasi Subramaniam
The paper investigates how uORFs buffer main ORF translation by causing ribosome stalls, showing this mechanism is insensitive to stall location and occurs via dissociation rather than queuing of scanning ribosomes.
PLoS Genetics · Oct 31, 2022Peer-reviewedMolecular Biology