Heungwon Park

This study uses ReLiC screens to analyze the effects of RNA-associated protein knockouts on RNA metabolism, revealing modular gene network interactions and pathway-specific coupling between growth fitness and mRNA translation.

This paper uses a deaminase-based RNA recording method to profile protein-RNA interactions by introducing nucleotide edits detectable via DNA sequencing, revealing conserved sequence requirements across different contexts.

The paper identifies sequence motifs that trigger co-translational mRNA decay in yeast using a massively parallel reporter assay and shows their predictive power for endogenous sequences.

The paper identifies dipeptide repeats that destabilize mRNA by causing ribosome stalling, revealing a nascent peptide code that influences mRNA stability in human cells.

The paper investigates how uORFs buffer main ORF translation by causing ribosome stalls, showing this mechanism is insensitive to stall location and occurs via dissociation rather than queuing of scanning ribosomes.

The paper shows that increased translation initiation in yeast can reduce mRNA stability and protein expression due to ribosome collisions, revealing an inverted control mechanism.