Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA transcripts is driven by intron retention: implications for RNA-directed therapies
G. Dumbovic, U. Braunschweig, H. K. K. Langner, K. Jastrzebska, M. Smallegan, B. Blencowe, T. R. Cech, M. H. Caruthers, J. L. Rinn
The paper shows that intron retention drives nuclear compartmentalization of TERT mRNA and TUG1 lncRNA, impacting cell growth and suggesting new RNA-based therapy targets.
bioRxiv · Jul 21, 2020 · PreprintCell Biology