A novel consensus-based computational pipeline for rapid screening of antibody therapeutics for efficacy against SARS-CoV-2 variants of concern including omicron variant
Naveen Kumar, Rahul Kaushik, Kam Y. J. Zhang, Vladimir Nikolaevich Uversky, Pratiksha Srivastava, Upasana Sahu, Richa Sood, Sandeep Bhatia
This paper introduces a computational pipeline to predict binding affinity of SARS-CoV-2 variants to hACE2 and neutralizing antibodies, showing Omicron variants have reduced binding to most RBD-directed antibodies.
Proteins Structure Function and Bioinformatics · Jan 11, 2023Peer-reviewedBioinformatics