Vladimir Nikolaevich Uversky

The paper quantifies compositional patterns in SRY proteins and HMG-box domains across mammals, revealing distinct compositional grammars and highlighting the need for alignment-independent analysis.

The paper uses simulations to analyze residue-level contact networks in IDRs, showing how phosphorylation rewires these networks and how force fields influence residue behavior.

AlphaFold3 pLDDT matches AlphaFold2 at calling disordered residues (Matthews correlation 0.693 vs 0.701); on disorder-containing complexes mean DockQ is similar, but interface features explain less variance (42% vs 58%).

The paper identifies 27 interactions between 13 TNFSF members and 21 S100 proteins using surface plasmon resonance, showing calcium-dependent binding and conserved binding sites.

This paper benchmarks AI structure predictors on fuzzy protein complexes, finding they consistently violate 30% of NOE restraints and show poor helicity correlation with thermodynamic expectations.

This study analyzes mammalian histamine receptor sequences to identify evolutionary patterns and structural constraints across species.

This study identifies narrow adaptive pathways for antifolate resistance in Plasmodium falciparum dihydrofolate reductase using a computational framework integrating mutational fitness, evolutionary interactions, and structural data.

This study investigates how HIV forms CPSF6 puncta and their fusion with nuclear speckles, identifying key domains and factors involved in this process and its role in viral persistence.

The paper identifies citrullination of tau as a novel posttranslational modification in Alzheimer's disease and tauopathy models, showing its association with disease progression.

The paper analyzes the impact of CpG island architecture on amino acid usage and sequence complexity in human essential proteins, revealing compositional stratification and positional biases.

This study analyzes 165 GAPDH sequences to show that multifunctionality is encoded through compositional signatures and conserved spatial architecture, enabling metabolic stability and regulatory plasticity.

This study shows CDKN1A stabilizes cyclin D3 by inhibiting its phosphorylation-dependent nuclear export after butyrate treatment, revealing a mechanism for butyrate-induced cell cycle arrest.

The paper identifies glycosylation of serine/threonine-rich IDRs in streptococcal membrane proteins and shows its role in biofilm formation.

The paper identifies a critical substructure in DHPS through evolutionary and structural analyses, suggesting it as a target to constrain evolvability and disrupt antibiotic resistance.

This study quantitatively analyzes E. coli moonlighting proteins to identify patterns in amino acid composition and structural-functional relationships.

This study analyzes the molecular features of PRAME and BAP1 proteins in melanoma using bioinformatics methods to identify potential therapeutic targets.

This study identifies citrullination as a novel irreversible post-translational modification of TDP-43 linked to structural changes, aggregation, and pathology in TDP-43 proteinopathies.

This study analyzes 18 Methuselah protein variants in fruit flies, identifying evolutionary clades, functional subclasses, and structural features related to aging and longevity.

This study uses computational methods to analyze the mutational landscape of Plasmodium falciparum DHFR, revealing evolutionary pathways and co-evolving networks that contribute to antifolate resistance.

This study analyzes genetic variations in PAH and SMN1 genes associated with PKU and SMA in Saudi Arabia using quantitative techniques to improve diagnostics and treatments.

This study analyzes NSP14 mutations in SARS-CoV-2 to understand their role in viral evolution and variant diversification.

This study analyzes human moonlighting proteins using phylogenetic methods to explore their distal-proximal relationships and identify evolutionary hotspots.

The paper analyzes the role of intrinsically disordered proteins/regions in aging-related processes, finding they are prevalent in genome regulation and associated with aging hallmarks.

The paper investigates receptor sequences across vertebrate species to understand their relationship with mating behavior, finding that genetic and epigenetic factors influence behavioral patterns beyond direct genomic translation.

This paper introduces a computational pipeline to predict binding affinity of SARS-CoV-2 variants to hACE2 and neutralizing antibodies, showing Omicron variants have reduced binding to most RBD-directed antibodies.

The paper analyzes SARS-CoV-2 variants to show decreasing pathogenicity and pro-inflammatory cytokines, increasing antigenicity and anti-inflammatory cytokines, and rising structural protein instability across variants.

The paper compares sweet and bitter taste receptor genomics across 20 vertebrates to assess functional proximity and ligand binding affinity similarities.

The paper identifies 47 unique truncated ORF8 protein variants in B.1.1.7 SARS-CoV-2 sequences and defines nine possible variants based on physicochemical properties.

The paper analyzes S-protein variants of SARS-CoV-2 from six continents, finding North America has the most unique variants, which may spread globally, suggesting travel restrictions and vaccine updates are needed.