Reciprocal regulation of pancreatic ductal adenocarcinoma growth and molecular subtype by HNF4α and SIX1/4
S. A. Camolotto, V. Belova, L. Torre-Healy, J. Vahrenkamp, K. Berrett, H. Conway, C. Stubben, R. Moffitt, J. Gertz, E. Snyder
This study shows HNF4α suppresses PDAC growth and promotes the Classical subtype by repressing SIX1/4, which are critical for Basal-like subtype proliferation.
bioRxiv · Oct 22, 2019Cancer Biology