A framework to identify antigen-expanded T Cell Receptor (TCR) clusters within complex repertoires
V. Ceglia, E. J. Kelley, A. S. Boyle, Y. Levy, G. Zurawski, J. A. Altin
This paper introduces a framework to identify antigen-specific TCR clusters in complex repertoires using deep sequencing and antigen-driven expansion, enabling personalized antigen assignment without cell isolation.
bioRxiv · May 21, 2021Immunology