Single-molecule imaging with cell-derived nanovesicles reveals early binding dynamics at a cyclic nucleotide-gated ion channel
V. R. Patel, A. M. Salinas, D. Qi, S. Gupta, D. J. Sidote, M. P. Goldschen-Ohm
The paper uses cell-derived nanovesicles and single-molecule imaging to study ligand binding dynamics at a cyclic nucleotide-gated ion channel, revealing previously undetected conformational changes and non-cooperative binding behavior.
bioRxiv · Jul 5, 2021Biophysics