M. P. Goldschen-Ohm

This study investigates how mutations in the M2-M3 linkers of GABAA receptor subunits affect the closed-open equilibrium and diazepam modulation.

This paper identifies structural elements in the OTOP channel family that mediate Zn2+ activation, revealing the tm 11-12 linker as part of the gating apparatus.

The paper uses cell-derived nanovesicles and single-molecule imaging to study ligand binding dynamics at a cyclic nucleotide-gated ion channel, revealing previously undetected conformational changes and non-cooperative binding behavior.