Demultiplexing overlapping signaling scaffold functions to probe lipid messenger coupling to cytoskeletal dynamics.
N. J. Trenton, R. T. McLaughlin, S. Bellamkonda, D. Tsao, E. Mace, j. orange, V. Schweikhard, M. R. Diehl
This study uses live-cell imaging and statistical analyses to show IQGAP1 regulates actin dynamics around endosomes through PIP3-dependent tethering and transient inhibition of actin growth.
bioRxiv · Jun 14, 2019 · PreprintBiophysics