A generic binding pocket for small molecule IKs activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexes
M. Chan, H. Sahakyan, J. Eldstrom, D. Sastre, Y. Wang, Y. Dou, M. Pourrier, V. Vardanian, D. Fedida
The paper identifies a generalized binding pocket for small molecule IKs activators at the extracellular interface of KCNQ1 and KCNE1 channel complexes, explaining their mechanism and guiding future drug design.
bioRxiv · Feb 27, 2023 · PreprintPharmacology & Toxicology