Author

H. Sahakyan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Evolutionary Biology· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Approach:mechanistic / dynamical model· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1

Frequent Co-Authors

A. Kotsinyan· 1 shared A. Mushegian· 1 shared D. Fedida· 1 shared D. Sastre· 1 shared E. V. Koonin· 1 shared H. Zakaryan· 1 shared I. Sorokina· 1 shared J. Eldstrom· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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1 shared paperEvolutionary Biology

A. Kotsinyan

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

CoCoNuTs: A diverse subclass of Type IV restriction systems predicted to target RNA

R. T. Bell, H. Sahakyan, K. S. Makarova, Y. I. Wolf, E. V. Koonin

The paper identifies and characterizes CoCoNuTs, a new subclass of Type IV restriction systems that target RNA, with additional potential DNA targeting capabilities and regulatory mechanisms.

bioRxiv · Jul 31, 2023Microbiology

A generic binding pocket for small molecule IKs activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexes

M. Chan, H. Sahakyan, J. Eldstrom, D. Sastre, Y. Wang, Y. Dou, M. Pourrier, V. Vardanian, D. Fedida

The paper identifies a generalized binding pocket for small molecule IKs activators at the extracellular interface of KCNQ1 and KCNE1 channel complexes, explaining their mechanism and guiding future drug design.

bioRxiv · Feb 27, 2023 · PreprintPharmacology & Toxicology

Identification of the Branching Order within the Kingdom Bamfordvirae

A. Kotsinyan, H. Sahakyan, H. Zakaryan

This paper refines the branching order within the Bamfordvirae kingdom by analyzing phylogenetic data, revealing new phylogenetic relationships and suggesting taxonomic revisions.

bioRxiv · May 25, 2022 · PreprintEvolutionary Biology

Energy-dependent protein folding: modeling how a protein folding machine may work

H. Sahakyan, K. Nazaryan, A. Mushegian, I. Sorokina

The paper proposes that protein folding in vivo is an energy-dependent process and demonstrates this using molecular dynamics simulations with mechanical force applied to peptide backbones.

bioRxiv · Sep 1, 2020Biochemistry