Structure of the processive human Pol δ holoenzyme
C. Lancey, M. Tehseen, V.-S. Raducanu, F. Rashid, N. Merino, T. J. Ragan, C. Savva, M. S. Zaher, A. Shirbini, F. J. Blanco, S. M. Hamdan, A. De Biasio
This study presents the high-resolution cryo-EM structure of the human Pol δ-DNA-PCNA complex with and without FEN1, revealing its structural basis for DNA replication.
bioRxiv · Dec 11, 2019Biochemistry