Coupled Transcriptomic and ECM-Mechanical Remodeling Reveal Mechanotransductive Pathways in Spinal Cord Injury
Elif Ertrugal, Vasanti Dhakate, Rounak Pokharel, Gowsia Banu Shaik, Jessica Onyak, Peng Jiang, Chandrasekhar R. Kothapalli, Nic D. Leipzig
This study investigates the mechanical and transcriptomic changes in spinal cord injury, showing how evolving tissue mechanics and mechanotransduction regulate ECM remodeling and hinder regeneration.
bioRxiv · Jul 8, 2026 · PreprintNeuroscience