Chandrasekhar R. Kothapalli

This study investigates the mechanical and transcriptomic changes in spinal cord injury, showing how evolving tissue mechanics and mechanotransduction regulate ECM remodeling and hinder regeneration.

This study shows that biomechanical cues like shear stress and mechanical strain influence fibroblast behavior and fibrotic remodeling in a gut-on-a-chip model, with epithelial barriers protecting against damage.

This paper demonstrates that biosponge scaffolds loaded with GDNF enhance neuromuscular junction recovery and muscle function after volumetric muscle loss in rats.

This study models peracetic acid decay and Salmonella inactivation during poultry chilling, showing that PAA concentration and exposure time are critical for bacterial inactivation, especially in the presence of organic load.

This study shows that Wnt activation in mature dermal adipocytes causes lipodystrophy and skin fibrosis, which can be reversed by stopping Wnt activation.

The paper develops a reaction-diffusion-advection model to capture spatial and temporal bacterial dynamics in poultry chilling, showing it reaches steady state within 2 hours and accurately predicts E. coli levels on carcasses.

This study examines how chronic hyperglycemia affects human aortic smooth muscle cells, revealing changes in gene expression, protein levels, and metabolic profiles linked to cardiovascular disease.

This study identifies AF-associated SNPs in SYNE2 that reduce SYNE21 expression and increase nuclear stiffness, potentially contributing to AF pathogenesis.