Systemic Proteome Phenotypes Reveal Defective Metabolic Flexibility in Mecp2 Mutants
Stephanie A. Zlatic, Erica Werner, Veda Surapaneni, Chelsea E. Lee, Avanti Gokhale, Kaela S. Singleton, Duc Minh Duong, Amanda J. Crocker, Karen L. Gentile, Frank A. Middleton, Joseph Martin Dalloul, William Li-Yun Liu, Anupam Patgiri, Daniel Charles Tarquinio, Randall Carpenter, Victor Faúndez
The paper identifies systemic proteome and transcriptome changes in Mecp2 mutants, revealing impaired metabolic flexibility across multiple organs and brain regions.
Human Molecular Genetics · Sep 13, 2023Peer-reviewedNeuroscience