This study investigates how a genetic polymorphism in ADRA2B affects responses to vagus nerve stimulation, finding it influences pupillary responses and cortical activity alignment with noradrenergic projections.

bioRxiv · Nov 3, 2026 · PreprintNeuroscience

Dengue virus structural proteins are expressed on the surface of DENV-infected cells and are a target for antibody-dependent cellular phagocytosis

Mitchell J. Waldran, Elizabeth A Kurtz, C. J. Gebo, Timothy J Rooney, Frank A. Middleton, Nathan H. Roy, Jeffrey R. Currier, Adam Tully Waickman

This study shows DENV structural proteins are surface-expressed on infected cells and can be targeted by antibodies for phagocytic clearance, bypassing ADE risks.

Open Forum Infectious Diseases · Dec 10, 2024Peer-reviewedImmunology

Systemic Proteome Phenotypes Reveal Defective Metabolic Flexibility in Mecp2 Mutants

Stephanie A. Zlatic, Erica Werner, Veda Surapaneni, Chelsea E. Lee, Avanti Gokhale, Kaela S. Singleton, Duc Minh Duong, Amanda J. Crocker, Karen L. Gentile, Frank A. Middleton, Joseph Martin Dalloul, William Li-Yun Liu, Anupam Patgiri, Daniel Charles Tarquinio, Randall Carpenter, Victor Faúndez

The paper identifies systemic proteome and transcriptome changes in Mecp2 mutants, revealing impaired metabolic flexibility across multiple organs and brain regions.

Human Molecular Genetics · Sep 13, 2023Peer-reviewedNeuroscience

Mitochondrial protein import stress augments alpha-synuclein aggregation and neurodegeneration independent of bioenergetics

Liam P. Coyne, Arnav Rana, Xiaowen Wang, Sanaea Z. Bhagwagar, Yumiko Umino, Eduardo C. Solessio, Frank A. Middleton, Xin Jie Chen

This study shows that mitochondrial protein import stress increases alpha-synuclein aggregation and neurodegeneration without affecting bioenergetics in a Parkinson's disease mouse model.

bioRxiv · Sep 20, 2022 · PreprintMolecular Biology