Impacts of competition and phenotypic plasticity on the viability of adaptive therapy
B. Vibishan, Paras Jain, Vedant Sharma, Kishore Hari, Claus Kadelka, Jason Thomas George, Mohit Kumar Jolly
This paper develops a deterministic model to study how competition and phenotypic plasticity affect adaptive therapy outcomes in cancer, showing that phenotypic transitions can complicate therapy and that asymmetric competition benefits treatment.
Mathematical Biosciences · Nov 1, 2025Peer-reviewedSystems Biology