Paras Jain

This paper introduces WENDy, a method for parameter estimation in systems biology models using weak-form regression, demonstrating its application on real experimental data for glycolytic oscillators and cell-state transitions.

The paper shows hypoxic memory in cancer cells affects tumor invasion dynamics through time-dependent changes in cell state and spatial oxygen dynamics.

This paper develops a PDE framework to model hypoxic memory's impact on tumor invasion under cyclic hypoxia, showing enhanced invasion without reduced tumor volume.

This paper develops a deterministic model to study how competition and phenotypic plasticity affect adaptive therapy outcomes in cancer, showing that phenotypic transitions can complicate therapy and that asymmetric competition benefits treatment.

This study develops a model to analyze how cellular memory and adaptation cost affect survival in fluctuating environments, finding that increased adaptation cost can improve growth by reducing mismatches between cell state and environment.

The paper models the dynamics of E-M heterogeneity in breast cancer cells, finding that cell-state transitions, not growth differences, are essential for explaining observed population dynamics.

The paper models phenotypic switching in cancer cells to explain spontaneous epithelial-mesenchymal heterogeneity through stochastic SNAIL partitioning during cell division.