X-SPEAR: An Extensible Framework for Spatial Panel Evaluation and Refinement
Rushil Patel, Bryant Duong, Veer Patel, Rachel Lyn-Sue, Kyungbin Oh, Yuyan Cheng
X-SPEAR improves spatial transcriptomics panel design by integrating detection-aware marker selection and probe-level off-target assessment, achieving higher accuracy with fewer genes.
bioRxiv · Oct 20, 2026 · PreprintGenomics