Author

Victoria Baskerville

Johns Hopkins University

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Neuroscience· 1

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Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Adrian M. IsaacsiD· 1 shared Alyssa N. CoyneiD· 1 shared Emma Mehlhop· 1 shared Frank Bennett· 1 shared Frank RigoiD· 1 shared Jeffrey D. RothsteiniD· 1 shared Paymaan Jafar‐NejadiD· 1 shared Sampath RapuriiD· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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9 top collaborators · 36 mutual co-author links

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1 shared paperNeuroscience

Adrian M. IsaacsORCID

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1 paper

Recent·Most cited

G2C4 targeting antisense oligonucleotides potently mitigate TDP-43 dysfunction in C9orf72 ALS/FTD human neurons

Jeffrey D. Rothstein, Victoria Baskerville, Sampath Rapuri, Emma Mehlhop, Paymaan Jafar‐Nejad, Frank Rigo, Frank Bennett, Sarah Mizielinska, Adrian M. Isaacs, Alyssa N. Coyne

This study shows that targeting G2C4 antisense repeat RNA, not G4C2 sense RNA, mitigates TDP-43 dysfunction in C9orf72 ALS/FTD patient neurons, explaining the failure of previous G4C2 ASO clinical trials.

bioRxiv · Jun 26, 2023 · PreprintNeuroscience