Reliability of Whole-Exome Sequencing for Assessing Intratumor Genetic Heterogeneity
Weiwei Shi, Charlotte K.Y. Ng, Raymond S. Lim, Tingting Jiang, Sushant Kumar, Xiaotong Li, Vikram B. Wali, Salvatore Piscuoglio, Mark Gerstein, Anees B. Chagpar, Britta Weigelt, Lajos Pusztai, Jorge Sergio Reis-Filho, Christos Hatzis
This study evaluates the reliability of whole-exome sequencing in detecting intratumor genetic heterogeneity, finding that technical noise accounts for a significant proportion of apparent genetic differences.
Cell Reports · Nov 1, 2018Peer-reviewedGenomics