Author

Tingting Jiang

Yale UniversityORCID 0000-0002-0789-8816Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:whole-exome sequencing· 3 Organism:human· 2 Research Focus:variant calling· 2 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Yuval KlugeriD· 2 shared Anees B. ChagpariD· 1 shared Anton Mikhailovich SafonoviD· 1 shared Britta WeigeltiD· 1 shared Charlotte K.Y. NgiD· 1 shared Charlotte Proudhon· 1 shared Chen ZhaoiD· 1 shared Christos HatzisiD· 1 shared

Activity by Year

2016-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBioinformatics

Yuval KlugerORCID

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4 papers

Recent·Most cited

TruSight Oncology 500: Enabling Comprehensive Genomic Profiling and Biomarker Reporting with Targeted Sequencing

Chen Zhao, Tingting Jiang, Jin Hyun Ju, Shile Zhang, Jenhan Tao, Yao Shi Fu, Jennifer S. LoCoco, Janel Dockter, Traci L. Pawlowski, Sven Bilke

The paper describes a targeted sequencing assay and bioinformatics workflow for comprehensive genomic profiling of cancer, achieving high accuracy in variant detection and biomarker assessment.

bioRxiv · Oct 21, 2020 · PreprintBioinformatics

Reliability of Whole-Exome Sequencing for Assessing Intratumor Genetic Heterogeneity

Weiwei Shi, Charlotte K.Y. Ng, Raymond S. Lim, Tingting Jiang, Sushant Kumar, Xiaotong Li, Vikram B. Wali, Salvatore Piscuoglio, Mark Gerstein, Anees B. Chagpar, Britta Weigelt, Lajos Pusztai, Jorge Sergio Reis-Filho, Christos Hatzis

This study evaluates the reliability of whole-exome sequencing in detecting intratumor genetic heterogeneity, finding that technical noise accounts for a significant proportion of apparent genetic differences.

Cell Reports · Nov 1, 2018Peer-reviewedGenomics

Methods for detecting co-mutated pathways in cancer samples to inform treatment selection

Tingting Jiang, Uri Shaham, Fabio Parisi, Ruth Halaban, Anton Mikhailovich Safonov, Harriet M. Kluger, Sherman M. Weissman, Joseph T. Chang, Yuval Kluger

The paper develops a method to detect co-mutated pathways in cancer samples and identifies enriched pathway pairs across six cancer types, suggesting potential mechanisms for immune evasion.

bioRxiv · Oct 22, 2016 · PreprintBioinformatics

The interdependent nature of multi-loci associations can be revealed by 4C-Seq

Tingting Jiang, Ramya Raviram, Pedro P Rocha, Valentina Snetkova, Charlotte Proudhon, Sana Badri, Richard Bonneau, Jane A Skok, Yuval Kluger

The paper introduces a method to identify multi-loci chromatin interactions using 4C-seq data and demonstrates its application to Tcrb and Igk enhancer interactions.

Nucleic Acids Research · Jul 20, 2016Peer-reviewedGenomics