The genomic and epigenomic evolutionary history of papillary renal cell carcinomas
Bin Zhu, Maria Luana Poeta, Manuela Costantini, Tongwu Zhang, Jianxin Shi, Steno Sentinelli, Zhao Wei, Vincenzo Pompeo, Maurizio Cardelli, Boian S. Alexandrov, Burçak Otlu, Xing Hua, Kristine M. Jones, Seth A. Brodie, Malgorzata Ewa Dabrowska, , Maria Teresa Landi
This study examines intratumor heterogeneity and clonal evolution in papillary renal cell carcinomas using whole-genome sequencing and DNA methylation data, revealing distinct patterns of genomic and epigenomic evolution across subtypes.
Nature Communications · Jun 18, 2020Peer-reviewedGenomics