Xing Hua

Evaluating Multi-Ancestry Genome-Wide Association Methods: Statistical Power, Population Structure, and Practical Implications

This study compares pooled analysis and meta-analysis for multi-ancestry GWAS, finding pooled analysis offers better statistical power while controlling population structure.

SurvBal: Compositional Microbiome Balances for Survival Outcomes

SurvBal identifies microbiome taxon balances associated with survival outcomes using survival models and step-wise selection.

Admix-kit: An Integrated Toolkit and Pipeline for Genetic Analyses of Admixed Populations

Admix-kit provides tools for genetic analysis of admixed populations, enabling simulation, association testing, and polygenic scoring.

A real-world pan-cancer catalogue of mutational signatures from 111,711 tumors

This paper introduces SATS, a framework for mutational signature analysis in targeted sequencing data, and presents a pan-cancer catalogue of mutational signatures from 111,711 tumors.

Estimating the overall fraction of phenotypic variance attributed to high-dimensional predictors measured with error

The paper estimates the fraction of phenotypic variance explained by high-dimensional genomic predictors with measurement error, using microbiome data from the American Gut Project.

Kernel-based genetic association analysis for microbiome phenotypes identifies host genetic drivers of beta-diversity

The paper introduces a kernel-based method to identify host genetic variants associated with microbiome beta-diversity, finding immunity-related genes influence gut microbiota composition.

The genomic and epigenomic evolutionary history of papillary renal cell carcinomas

This study examines intratumor heterogeneity and clonal evolution in papillary renal cell carcinomas using whole-genome sequencing and DNA methylation data, revealing distinct patterns of genomic and epigenomic evolution across subtypes.

Genetic and Epigenetic Intratumor Heterogeneity Impacts Prognosis of Lung Adenocarcinoma

This study quantifies genetic and epigenetic intratumor heterogeneity in lung adenocarcinoma and links it to poor prognosis.