Nuclear depletion of RNA binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis
Sandra Díaz-García, Vivian I. Ko, Sonia Vazquez‐Sanchez, Ruth Chia, Olubankole Aladesuyi Arogundade, Maria José Gómez-Rodríguez, Bryan J. Traynor, Don W. Cleveland, John Ravits
The paper identifies ELAVL3 as a downregulated RNA binding protein in ALS, showing nuclear depletion and mislocalization in motor neurons, with findings suggesting loss of function rather than cytoplasmic toxicity.
Acta Neuropathologica · Oct 7, 2021Peer-reviewedNeuroscience