Group Heteroscedasticity - A Silent Saboteur of Power and False Discovery in RNA-Seq Differential Expression
Suvo Chatterjee, Arindam Fadikar, Vrushab Hanumesh, Siddhant Sunil Meshram, Roger S. Zoh, Siyuan Ma, Ganesan Arunkumar, Himel Mallick
This paper introduces Robseq, a statistical model for RNA-Seq differential expression that addresses FDR inflation caused by group heteroscedasticity, showing improved control of false discovery and type-I error rates.
bioRxiv · Apr 1, 2024 · PreprintBioinformatics