Ganesan Arunkumar

This paper introduces SACOMA, a spatially-aware unsupervised method to identify co-methylated regions in DNA methylation data, improving sensitivity and false-positive control.

The paper investigates how an oncogenic lncRNA transgene affects epigenetic memory at a naive chromosomal locus, showing that epigenetic silencing can reverse ectopic CENP-A deposition over time.

This study shows H1.5 interacts with CENP-A nucleosomes at centromeres, and its depletion causes centromere dysfunction and mitotic defects in human cells.

This study examines how Valproic Acid affects chromosome flexibility and electron transport in MCF7 breast cancer cells using atomic force microscopy and electron transport analysis.

This paper introduces Robseq, a statistical model for RNA-Seq differential expression that addresses FDR inflation caused by group heteroscedasticity, showing improved control of false discovery and type-I error rates.

The paper identifies OIP5-AS1 as overexpressed in undifferentiated oral tumors and shows it modulates miRNAs and downstream targets, potentially maintaining cancer stemness through stemness-associated transcription factors.