Analysis of Local Variability and Allostery in Macromolecular Assemblies using Cryo-EM and Focused Classification
C. Zhang, W. Cantara, Y. Jeon, K. Musier-Forsyth, N. Grigorieff, D. Lyumkis
The paper develops focused classification strategies for single-particle cryo-EM to analyze structural variability and allostery, applying them to an HIV-1 TAR element RNA dataset.
bioRxiv · Jul 28, 2018Biophysics