Protein structure-informed deep learning enables species-specific codon optimization
W. J. Jin, Wuwei Tan, Hui Li, Xiangyu Ji, Ming Li, Deqiang Zhang, Jinbo Xu
PISCO improves codon optimization by integrating protein structure and host-specific codon usage, enhancing solubility and expression.
bioRxiv · Apr 24, 2026 · PreprintMolecular Biology