Structural Basis of Complex Formation Between Mitochondrial Anion Channel VDAC1 and Hexokinase-II
N. Haloi, P.-C. Wen, Q. Cheng, M. Yang, G. Natarajan, A. K. S. Camara, W.-M. Kwok, E. Tajkhorshid
This study investigates the structural basis of the HKII/VDAC1 complex formation using simulations and electrophysiological measurements, revealing partial blockade of VDAC1 and phosphorylation-dependent disruption of binding.
bioRxiv · Nov 18, 2020Biophysics