Off-target effects of PLX5622 revealed: mixing microglial function in anesthesia and addiction withdrawal
Kelei Cao, Wang Cheng, Liyao Qiu, Zexi Wang, Yuqing Zhao, Ying Yuan, Weiying Wu, Jingyuan Xue, Linghui Zeng, Zhi-Ying Wu, Huan Ma, Tingjun Hou, Cunqi Ye, Zhihua Gao
This study reveals that PLX5622 affects anesthetic emergence and nicotine-withdrawal anxiety through enhanced drug metabolism, not microglial depletion.
bioRxiv · Jul 18, 2025 · PreprintNeuroscience