Protein Phosphatase 2A Activation Attenuates Acute Myocardial Injury in Takotsubo Syndrome by Modulating Ferroptosis and Mitochondrial Injury in Cardiomyocytes
Wang Ti, Qian Xu, Jisheng Sun, Hildebrando Candido Ferreira Neto, Feng Dong, Colin T. Stomberski, Caitlin M. O’Connor, Goutham Narla, Daxin Wang, Zhiyong Lin
This study identifies PP2A inactivation as a key driver of myocardial injury in TTS, showing that restoring PP2A or inhibiting JNK reduces ferroptosis and mitochondrial dysfunction.
bioRxiv · Jul 28, 2026 · PreprintMolecular Biology