Qian Xu

BioSecBench-Function: A Verifiable Benchmark for Reasoning about Biological Function from Experimental Data

The paper introduces BioSecBench-Function, a benchmark for assessing AI agents' ability to infer biological function from experimental data, showing varying performance across models and tasks.

Protein Phosphatase 2A Activation Attenuates Acute Myocardial Injury in Takotsubo Syndrome by Modulating Ferroptosis and Mitochondrial Injury in Cardiomyocytes

This study identifies PP2A inactivation as a key driver of myocardial injury in TTS, showing that restoring PP2A or inhibiting JNK reduces ferroptosis and mitochondrial dysfunction.

Host EV derived lipids promote malaria parasite development via mosquito fatty acid oxidation

The paper shows that host-derived extracellular vesicles promote malaria parasite development in mosquitoes by reprogramming lipid metabolism through fatty acid oxidation.

Role of RSPO3 in Estrogen-mediated Sex Differences in Body Fat Distribution: A Single-cell Data-driven Study

This study investigates the role of RSPO3 in estrogen-mediated sex differences in body fat distribution using single-cell RNA sequencing and spatial transcriptomics in humans and mice.

Interpretable modeling of time-resolved single-cell gene-protein expression using CrossmodalNet

The paper introduces CrossmodalNet, an interpretable model that predicts surface protein expression from scRNA-seq data and incorporates temporal information to uncover gene-protein relationships.

scTenifoldKnk: an efficient virtual knockout tool for gene function predictions via single-cell gene regulatory network perturbation

scTenifoldKnk predicts gene function via virtual knockout using scRNA-seq data from wild-type samples, recapitulating real-animal KO results.