Is proteolytic cleavage essential for the activation of Hydra pore-forming toxin, HALT-4?
The study investigates whether proteolytic cleavage of HALT-4 enhances its cytolytic activity, finding that cleavage of KK1 and KK2 may facilitate sorting to the regulated secretory pathway rather than increasing cytotoxicity.
bioRxiv · Aug 13, 2022 · PreprintMolecular Biology