In Situ Structure Determination of a Membrane Protein in Native Cellular Membranes by Proton-Detected Solid-State NMR
Huayong Xie, Weijing Zhao, Hang Xiao, Yan Zhang, Yang Shen, Yuefang Gan, Qiong Tong, Yongxiang Zhao, Huan Tan, Jun Yang
This paper uses proton-detected solid-state NMR to determine the high-resolution structure of MscL in native E. coli membranes, achieving better sensitivity than 13C-detected methods.
bioRxiv · Oct 28, 2025 · PreprintBiophysics