Ribosome-tethered in situ sequencing for single-cell translatome analysis
Meng Jiang, Xiaojie He, Yanxiu Liu, Benchao Liu, Zhaoxiang Xie, Weiyan Ma, Lingyu Zhu, Chen Lin, Yongyou Zhang, Rongqin Ke
The paper introduces Ribo-ISS, a spatial translatomics method for single-cell translatome profiling in mouse brain, revealing transcription-translation uncoupling and cell-type-specific responses to sleep deprivation.
bioRxiv · Jul 28, 2026 · PreprintMolecular Biology