Author

Weiyan Zheng

Southern University of Science and Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:benchmarking· 2 Research Focus:gene regulatory network inference· 2 Assay:metabolomics· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:differential expression· 1

Frequent Co-Authors

Ziwei DaiiD· 3 shared Chuyun Ding· 2 shared Dan HuangiD· 2 shared Wenchao FaniD· 2 shared DONGXUAN CHI· 1 shared Jason W. LocasaleiD· 1 shared Jie Ding· 1 shared Jing NieiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersSystems Biology

Ziwei DaiORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Molecular anatomy of the glomerular filtration barrier reveals topology-encoded albumin sieving

Xing Wang, Weiyan Zheng, Wenjing Du, DONGXUAN CHI, Wenjia Fan, Ruoheng Mo, Jie Ding, Li Yang, Jing Nie, Ming Han, Qiang Guo

The paper uses cryo-ET and transport modeling to show that the glomerular basement membrane's void-network topology restricts albumin passage, explaining selectivity in the filtration barrier.

bioRxiv · Oct 18, 2026 · PreprintPhysiology

A universal law of thermodynamics-kinetics coupling shapes enzyme allocation and glycolytic efficiency across species

Kai Sun, Weiyan Zheng, Wenchao Fan, Chuyun Ding, Dan Huang, Ziwei Dai

The paper derives and validates a universal law of thermodynamics-kinetics coupling that governs glycolytic enzyme allocation across species under optimal efficiency.

bioRxiv · Sep 29, 2025 · PreprintSystems Biology

Unraveling principles of thermodynamics for genome-scale metabolic networks using graph neural networks

Wenchao Fan, Chuyun Ding, Dan Huang, Weiyan Zheng, Ziwei Dai

This paper introduces a graph neural network model to predict Gibbs free energy for metabolic reactions and identifies thermodynamic driver reactions in human metabolic networks.

bioRxiv · Jan 15, 2024 · PreprintSystems Biology

Amino acid variability, tradeoffs and optimality in human diet

Ziwei Dai, Weiyan Zheng, Jason W. Locasale

This study maps amino acid content in human diets, identifies health trade-offs, and constructs a Pareto front for optimal dietary protein intake.

Nature Communications · Nov 5, 2022Peer-reviewedSystems Biology