Author

Wenchao Fan

Southern University of Science and TechnologyORCID 0009-0005-6654-7003Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2

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Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:metabolomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Approach:graph neural network· 1 Organism:mouse· 1

Frequent Co-Authors

Chuyun Ding· 2 shared Dan HuangiD· 2 shared Weiyan Zheng· 2 shared Ziwei DaiiD· 2 shared Kai SuniD· 1 shared

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2024-2025 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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2 shared papersSystems Biology

Chuyun Ding

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2 papers

Recent·Most cited

Systems BiologybioRxivPreprintSep 29, 2025

A universal law of thermodynamics-kinetics coupling shapes enzyme allocation and glycolytic efficiency across species

Kai Sun, Weiyan Zheng, Wenchao Fan…·Ziwei Dai

The paper derives and validates a universal law of thermodynamics-kinetics coupling that governs glycolytic enzyme allocation across species under optimal efficiency.

DOI 10.1101/2025.09.29.679393

humanmouse

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Systems BiologybioRxivPreprintJan 15, 2024

Unraveling principles of thermodynamics for genome-scale metabolic networks using graph neural networks

Wenchao Fan, Chuyun Ding, Dan Huang…·Ziwei Dai

This paper introduces a graph neural network model to predict Gibbs free energy for metabolic reactions and identifies thermodynamic driver reactions in human metabolic networks.

1 citation

humanmetabolomics

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