Compartmental structure in the secondary lymphoid tissue can slow down in vivo HIV-1 evolution in the presence of strong CTL responses
Wen-Jian Chung, Dominik Wodarz
The paper shows compartmental structure in secondary lymphoid tissues slows HIV-1 evolution under strong CTL responses by reducing mutant fixation, generation, and invasion rates.
Journal of The Royal Society Interface · Feb 1, 2025Peer-reviewedEvolutionary Biology