Bioinformatic analysis and experimental validation of ursolic acid's effects on Staphylococcus aureus-induced osteomyelitis
Chengshuo Deng, Shuangli Chen, Wenen Huang, Longjie Miao, Yun Zhao, Huijun Zhu, Yumei Zhou, Lijun Zhao, Helu Liu
This study identifies ursolic acid's therapeutic mechanism against MRSA-induced osteomyelitis through network pharmacology, bioinformatics, and experimental validation, showing immunomodulation, anti-inflammatory effects, and direct antibacterial activity.
bioRxiv · Oct 10, 2025 · PreprintMicrobiology