Recombination and low-diversity confound homoplasy-based methods to detect the effect of SARS-CoV-2 mutations on viral transmissibility
Elena E. Giorgi, Tanmoy Bhattacharya A, Will Fischer, Hyejin Yoon, Werner Abfalterer, Bette Korber
The paper shows that recombination and low diversity reduce the sensitivity of homoplasy-based methods to detect increased transmissibility of the G614 SARS-CoV-2 variant.
bioRxiv · Jan 29, 2021 · PreprintBioinformatics