Elena E. Giorgi

The paper uses long-read sequencing to study HIV transmission and population dynamics in acute infection, finding high multilineage transmission rates and rapid viral evolution.

This paper develops updated HIV-1 pseudovirus panels to better detect and assess B cell lineages with potential to produce broadly neutralizing antibodies against contemporary HIV-1 variants.

This study examines HIV escape from two bNAbs in vivo, identifying recurrent mutations and genetic background dependencies in viral resistance.

The paper analyzes HIV breakthrough virus populations in antibody-mediated prevention trials, finding high rates of multilineage infections and recombination under VRC01 treatment.

The paper identifies shared maturation pathways of V3-glycan broadly neutralizing antibody lineages in humans and rhesus macaques, revealing convergent mutations and evolution patterns.

This study compares neutralization susceptibility of clade C HIV viruses from breastmilk to those from sexual transmission, finding breastmilk viruses more resistant to certain broadly neutralizing antibodies.

This study identifies VRC01-mediated viral escape mutations in HIV-infected participants from antibody-mediated prevention trials, showing that VRC01 can select for escape variants with cross-resistance to other CD4bs bnAbs.

The paper shows that recombination and low diversity reduce the sensitivity of homoplasy-based methods to detect increased transmissibility of the G614 SARS-CoV-2 variant.

The paper identifies infant-transmitted HIV-1 variants that are neutralization-resistant to maternal plasma but sensitive to broadly neutralizing antibodies, suggesting maternal antibody responses select for these resistant variants during peripartum transmission.