Chronic subthreshold intermittent theta burst stimulation promotes structural axon initial segment plasticity in cortical neurons
Emma King, Liz Jaeschke-Angi, Hakuei Fujiyama, Wicliffe Abraham, Jennifer Rodger, John N. J. Reynolds, Darren Clarke, Jamie L. Beros, Alexander D. Tang
This study shows that chronic intermittent theta burst stimulation (iTBS) induces axon initial segment (AIS) plasticity in cortical neurons, both in vitro and in vivo, suggesting non-synaptic mechanisms of rTMS effects.
bioRxiv · Apr 28, 2026 · PreprintNeuroscience