Distinct epigenetic shift in a subset of Glioma CpG island methylator phenotype (G-CIMP) during tumor recurrence
Camila Ferreira de Souza, Thais S. Sabedot, Tathiane M. Malta, Lindsay Stetson, Olena Morozova, Artem Sokolov, Peter W. Laird, Maciej Wiznerowicz, Antonio Iavarone, James Snyder, Ana deCarvalho, Zachary Sanborn, Kerrie L. McDonald, William A. Friedman, Daniela Tirapelli, , Houtan Noushmehr
The paper identifies an epigenetic shift from G-CIMP-high to G-CIMP-low in gliomas during recurrence, associated with genomic instability and stem cell-like features, and proposes biomarkers for predicting recurrence.
bioRxiv · Jun 28, 2017 · PreprintCancer Biology