Ana C. deCarvalho

The paper integrates single-nucleus RNA and ATAC sequencing to identify cellular states and regulatory networks associated with the G-CIMP epigenomic transition in IDH-mutant gliomas.

This study identifies local translation as a driver of glioblastoma tumor microtubes and invasion by linking subcellular protein synthesis to invasive cell states.

This study examines how genomic background and developmental state affect signaling pathways and therapy response in GBM patient-derived cells, finding that differentiation increases TMZ resistance and activates DNA-damage interferon responses.

The paper describes methods to study 3D cell cycle dynamics of glioma stem cells using fluorescent reporter systems and bioinformatics analysis.

This paper describes methods for generating zebrafish PDX systems to study GSC-mediated tumorigenesis and interactions with the tumor microenvironment.

This study analyzes the epigenetic evolution of IDH1-mutant and IDH1-wildtype gliomas under treatment, showing IDHmut tumors undergo epigenomic changes resembling IDHwt tumors, with implications for treatment strategies.

The paper analyzes tumor-intrinsic gene expression subtypes in IDH wild type glioblastomas and their association with immune microenvironment changes during recurrence.

The paper identifies an epigenetic shift from G-CIMP-high to G-CIMP-low in gliomas during recurrence, associated with genomic instability and stem cell-like features, and proposes biomarkers for predicting recurrence.