Nucleosome-mediated conformational switches in micro-eccDNAs
Sarah Anne Harris, Victor Velasco-Berrelleza, William Sandel, Thana Sutthibutpong, Victoria Nicole Parikh, Euan Angus Ashley, Andrew Z. Fire, Stephen D. Levene, Thomas Connor Bishop, Massa J. Shoura
The paper studies a 358-bp micro-eccDNA from the human Titin gene, showing nucleosomes induce a topological switch between intact and denatured states.
bioRxiv · Jun 14, 2025 · PreprintBiophysics