Andrew Z. Fire

This paper identifies a new mode of chromosome-end instability in cancer using circular DNA analysis, revealing a distinct spatial signature called EDGE.

The paper identifies pseudouridylated RNA in bacteriophages and shows host enzymes modify phage genomes to enhance virus production.

This study shows that a yeast prion domain can induce a heritable state in C. elegans that persists across generations and is reversible.

This study identifies the Type IX Secretion System as a key virulence factor in Chryseobacterium nematophagum's ability to kill Caenorhabditis elegans.

The paper identifies ZNF-236 as a key factor maintaining quiescence of stress-induced genes in C. elegans, showing that this silencing is an active genomic state, not passive.

The paper presents a new gap-free, telomere-to-telomere reference genome for C. elegans, CGC1, improving upon previous assemblies and providing a more complete genome.

The paper studies a 358-bp micro-eccDNA from the human Titin gene, showing nucleosomes induce a topological switch between intact and denatured states.

The paper identifies a new class of viroid-like elements, Obelisks, prevalent in human microbiomes and capable of persistent colonization.

This paper develops a toolkit for live imaging of whole-body regeneration in flatworms, revealing neuron regenerative limitations and independent nerve cord reconnection.

The paper investigates the evolutionary origins of large neuronal genes, finding they predate animal diversification and have expanded in complexity across species.

The paper introduces a computational method to detect DNA termini using direct and indirect readouts, revealing multiple initiation sites for HIV plus-strand synthesis.

The paper performs a meta-metagenomic search to identify potential environmental niches for 2019-nCoV by analyzing virome datasets from the NCBI Sequence Read Archive.

The paper introduces a software tool for analyzing DNA fragment size distributions using gel electrophoresis images, offering a cost-effective alternative to commercial systems.

The paper identifies and characterizes endogenous circular DNA (eccDNA) in C. elegans and human cells using unbiased methods, showing eccDNA originates from both coding and noncoding regions.