Tau-Associated Neuronal Loss in the Intermediate Nucleus of the Human Hypothalamus (VLPO Analog): Unveiling the Basis of NREM Sleep Dysfunction in PSP and Alzheimer's Disease
Shima Rastegar‐Pouyani, Caroline Horton Lew, Felipe L. Pereira, Abhijit Satpati, Vítor Ribeiro Paes, Renata Elaine Paraízo Leite, Cláudia Kimie Suemoto, Salvatore Spina, Helmut Heinsen, William W. Seely, Christine M. Walsh, Thomas C. Neylan, Lea T. Grinberg
This study examines neuronal loss and tau pathology in the hypothalamic intermediate nucleus of AD and PSP patients, linking these changes to distinct sleep disturbances.
bioRxiv · Mar 11, 2025 · PreprintNeuroscience