Lea T. Grinberg

The SWAN atlas: an open multimodal resource combining neuroimaging and high-resolution histology of the human brain in stereotactic space

The paper presents the SWAN atlas, a multimodal resource combining neuroimaging and high-resolution histology of the human brain in stereotactic space to improve localization accuracy for clinical applications.

Large-scale cerebrospinal fluid proteomics identifies diagnostic biomarker candidates across the clinico-pathological continuum of frontotemporal lobar degeneration

The paper identifies potential diagnostic biomarkers for frontotemporal lobar degeneration subtypes using cerebrospinal fluid proteomics.

Tau-induced mitochondrial reverse electron transport drives neurodegeneration

This study shows that tau regulates mitochondrial reverse electron transport, leading to ROS production and neurodegeneration, and identifies potential therapeutic targets.

Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice

This study shows that transplanting wild-type human iPSC-derived microglia into progranulin-deficient mice reduces neuropathology, circuit dysfunction, and behavioral issues in a FTD model.

Single-cell transcriptomic atlas of frontoinsular cortex reveals molecular correlates of selective neuronal vulnerability in FTD

The paper identifies molecular subtypes of neurons in the frontoinsular cortex and links specific gene expression patterns to neuronal vulnerability in FTD.

TAF15 amyloids propagate via defined motifs in a prion-like fashion

This study shows TAF15 forms amyloid fibrils and propagates prion-like between cells, identifying specific motifs that drive its aggregation in vitro and in cells.

Shared lipidome and proteome signatures of frontotemporal lobar degeneration and Alzheimer's disease

The paper identifies shared lipid and proteomic alterations in frontotemporal lobar degeneration and Alzheimer's disease, with greater changes in FTLD frontal cortex.

Targeted proteomics of postmortem human brain reveals neurobiologic heterogeneity in Alzheimer's disease using NULISA technology

This study uses targeted proteomics to identify protein expression differences in Alzheimer's disease cases with varying clinical and neuropathological features.

Characterisation of Posterior Predominant Amyloid PET Binding Across Multiple Cohorts

This paper identifies a posterior predominant amyloid PET binding pattern in multiple cohorts, showing its clinical and biological relevance and suggesting the need for more nuanced analysis methods.

Single-nucleus epigenomic dysregulation unmasks genetic risk-associated neurodegenerative glia states

The paper identifies glial cell-specific regulatory elements and genetic risk modifiers in tau-related dementias using single-nucleus epigenomic profiling.

Single-nucleus transcriptomics identifies a shared vulnerable excitatory neuronal population across typical and atypical Alzheimers disease

Distinct tau filament folds in familial frontotemporal dementia due to the MAPT S305I mutation

This study identifies distinct tau filament structures in FTLD-tau caused by the MAPT S305I mutation, revealing a unique 4-layer architecture and potential RNA-like polyanion binding.

Pathogenic tau inhibits synaptic plasticity by blocking eIF4B-mediated local protein synthesis

β-Amyloid Induces Microglial Expression of GPC4 and APOE Leading to Increased Neuronal Tau Pathology and Toxicity

This study shows that β-amyloid induces microglial GPC4 and APOE, which increases neuronal tau pathology and toxicity.

Developmental Plasticity and Stromal Co-option Shape a Pituitary Neuroendocrine Tumor Transcriptional Continuum

This study uses snRNA-seq and spatial transcriptomics to show PitNETs exhibit transcriptional continuity and originate from different developmental pathways, influenced by stromal interactions.

Interrogating the plasma proteome of repetitive head impact exposure and chronic traumatic encephalopathy

This study identifies plasma proteomic signatures associated with repetitive head impact exposure and CTE, linking them to immune, mitochondrial, and metabolic pathways and cognitive decline.

Extracellular Ca2+-Sensing Receptor (CaSR) Regulates Hypothalamic Function to Control Energy and Skeletal Metabolism in Mice

This study shows that neuronal CaSR regulates energy and skeletal metabolism by modulating hypothalamic function in mice, affecting growth, bone mass, and metabolic parameters.

Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing

This study identifies genetic risk factors for FTLD-TDP subtypes using whole-genome sequencing and meta-analysis across multiple cohorts.

Tau-Associated Neuronal Loss in the Intermediate Nucleus of the Human Hypothalamus (VLPO Analog): Unveiling the Basis of NREM Sleep Dysfunction in PSP and Alzheimer's Disease

This study examines neuronal loss and tau pathology in the hypothalamic intermediate nucleus of AD and PSP patients, linking these changes to distinct sleep disturbances.

Adhesion G protein-coupled receptor ADGRG1 promotes protective microglial response in Alzheimer's disease

This study shows that ADGRG1 in microglia helps protect against Alzheimer's disease by improving amyloid clearance and reducing pathology.

Spatially conserved pathoprotein profiling in the human suprachiasmatic nucleus in progressive Alzheimer disease stages

The paper examines molecular and pathological changes in the suprachiasmatic nucleus across Alzheimer's disease stages, finding SCN-specific tau pathology and immune dysregulation.

The wake- and sleep-modulating neurons of the lateral hypothalamic area demonstrate a differential pattern of degeneration in Alzheimers disease

This study examines the differential degeneration of wake- and sleep-modulating neurons in Alzheimer's disease, finding significant loss of orexinergic neurons and relative preservation of MCHergic neurons.

KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss

This study shows that CT-KIBRA repairs synaptic plasticity and memory in tauopathy models by stabilizing PKMζ, without altering tau levels or preventing synapse loss.

Disease-specific selective vulnerability and neuroimmune pathways in dementia revealed by single cellgenomics

The paper uses single-cell genomics to identify shared and disease-specific cell states and gene regulatory networks in three dementias, revealing distinct neuroimmune mechanisms and potential therapeutic targets.

Global and local ancestry modulate APOE association with Alzheimer's neuropathology and cognitive outcomes in an admixed sample

The paper examines how global and local ancestry influence the association between APOE ε4 and Alzheimer's neuropathology and cognitive outcomes in an admixed Brazilian cohort.

Genome-wide association study of autopsy-confirmed Multiple System Atrophy identifies common variants near ZIC1 and ZIC4

Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

This study shows that microglial NF-κB signaling drives tau spreading and toxicity in a mouse model of tauopathy, with inhibition reducing tau pathology and cognitive deficits.

Loss of lamin-B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus

This study identifies loss of lamin-B1 and nuclear deformations as markers of astrocyte senescence in vitro and in aged human hippocampus.

Caspase inhibition mitigates tau cleavage and neurotoxicity in iPSC-induced neurons with the V337M MAPT mutation

This study shows that caspase inhibition reduces tau cleavage and neurotoxicity in iPSC-derived neurons with the V337M MAPT mutation.

Molecular characterization of selectively vulnerable neurons in Alzheimer's Disease

The paper identifies molecular signatures of selectively vulnerable neurons in Alzheimer's Disease using single-nucleus RNA sequencing and validates findings with neuropathological methods.